Marrubium parviflorum Fisch. & C.A.Mey.; phytochemical constituents and antioxidant activity
نویسندگان
چکیده مقاله:
Background and objectives: Marrubium parviflorum Fisch. & C.A.Mey. (Lamiaceae) is a medicinal plant with documented antioxidant and analgesic effects distributed in Iran and Turkey. In the present study, the aerial parts of this species were subjected to phytochemical analysis, as well as antioxidant activity assays. Methods: Antioxidant activity of the petroleum ether, chloroform, ethyl acetate and n-butanol fractions of M. parviflorum aerial parts were evaluated using DPPH free radical-scavenging assay. Phytochemical constituents of the fractions having the most antioxidant activity were investigated on silica gel (normal and reversed phases) and sephadex LH-20 columns. Structures of the isolated compounds were elucidated using 1H-NMR, 13C-NMR and UV spectral analyses. Result: In DPPH free radical-scavenging assay, the ethyl acetate and n-butanol fractions demonstrated considerable antioxidant activity with IC50 values of 84.1 ± 5.1 and 85.6 ± 3.4 µg/mL, respectively. Phytochemical investigation of the mentioned fractions resulted in the isolation of eleven compounds including forsythoside B (1), verbascoside (2), quercetin-3-O-rutinoside (3), chlorogenic acid (4), quercetin-3-O-β-D-glucopyranoside (5), 1,5-dicaffeoylquinic acid (cynarin) (6), 4,5-dicaffeoylquinic acid (7), caffeic acid glucoside (8), chrysoeriol 7-O-(3''-O-E-p-coumaroyl)-β-D-glucopyranoside (9), chrysoeriol 7-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside (10) and apigenin 7-O-(6''-O-E-p-coumaroyl)-β-D-glucopyranoside (11). Conclusion: The results of this study introduced M. parviflorum as a plant rich in flavonoids, phenylethanoid glycosides and caffeoylquinic acid derivatives. A review on biological activity of the isolated compounds suggested the possible involvement of these compounds in previously reported antioxidant and analgesic activity of M. parviflorum. These findings were also indicated more medicinal potential of M. parviflorum and highlighted the species for further biological studies.
منابع مشابه
Antimicrobial Activity of Different Extracts and Fractions of Marrubium parviflorum
Background and purpose: Marrubium plants have long been used as a traditional medicine in treatment of diseases. The aim of this study was to evaluate the antimicrobial effects of Marrubium parviflorum extracts and fractions. Materials and methods: In this experimental study, solvent extraction from aerial parts of the plant was done by Soxhlet method. The antimicrobial effect of the extracts ...
متن کاملDay time trend in the phytochemical constituents and antioxidant activity of Azadirachta indica leaves
Background & Aim:Medicinal plants have been of immense therapeutic values to many communities, some traditional folklore places emphasis on collecting plants during the day for medicinal purpose. This study examined the effect of collection time on the phytochemical composition and antioxidant activity of Azadirachta indica leaves. Experimental: ...
متن کاملPhytochemical constituents, antioxidant activity and toxicity potential of the essential oil from Ferula gummosa Boiss. roots
Background and objectives: Ferula gummosa Boiss. (Umbelliferae) is a popular medicinal plant, which is known mostly for therapeutic uses of its oleo-gum-resin (Barijeh in Persian). In the present study, the essential oil of F. gummosa roots was investigated for its phytochemical constituents, antioxidant activity and toxicity potential. Method...
متن کاملPhytochemical constituents, antioxidant activity and toxicity potential of Phlomis olivieri Benth.
Background and objectives: Phlomis olivieri Benth. (Lamiaceae) is a medicinal plant widely distributed in Iran. In the present study, we have investigated the phytochemical constituents, antioxidant activity and general toxicity potential of the aerial parts of this species. Methods: Silica gel (normal and reversed phases) and Sephadex LH-20 colu...
متن کاملPhytochemical constituents, antioxidant activity, and antiproliferative properties of black, red, and brown rice bran
BACKGROUND In the recent years, the health benefits of the pigmented rice varieties have reported due to the presence of bioactive compounds. In this study, the phytochemical constituents (total phenolic, flavonoid and anthocyanin content) and individual phenolics and flavonoids of the extracts of sixteen genotypes of pigmented rice bran were evaluated using spectrophotometric and ultra-high pe...
متن کاملMarrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties.
Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic o...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 4 شماره Supplement
صفحات 79- 79
تاریخ انتشار 2017-11-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023